ⓘ रोगशास्त्र


ⓘ रोगशास्त्र

Pathology is the study of the processes underlying disease र other forms of illness, harmful abnormality, or dysfunction. Within biology but also a branch of medicine, it means specifically the study र diagnosis of the structural र functional changes in cells, tissues र organs that underlie disease. Pathology as a field of knowledge hence forms the basis of the scientific reasoning behind the practice of medicine.


1. Scope of pathology

The primary goal of pathology is the study of the four main aspects of a disease:

  • Clinical significance: the functional consequences of the morphologic changes
  • Pathogenesis: the mechanism by which a certain etiological factor causes disease
  • Morphologic changes: the structural changes induced in the cells, tissues र organs
  • Etiology: what causes the disease

2. Pathologists work

Because the public rarely meets pathologists, their work is not well understood. Pathology is a large र diverse field that allows a pathologist to participate in multiple areas of the field or focus their scope to a specific area. Essential to everyday surgeries, pathologists are responsible for processing र reporting on all specimens generated during surgery. Tissue samples are taken from the submitted specimens, stained, र processed for microscopic evaluation. Microscopic examination searches for disease of any type र this information is returned to the surgeon via a pathology report. Pathologists are also responsible for laboratory specimens. They, along with medical technologists, process specimens at medical laboratories for interpretations. In other words, when a doctor refers to a "laboratory result", they are not referring to a number generated by a black box; instead, it is the interpretation of a value by a pathologist or a technologist. It is also important to understand that a different laboratory might produce a different value on the same specimen. Pathologists are also called upon to perform autopsies. Autopsies represent less than ५% of the workload of a typical modern pathologist. There exists a subspecialty in pathology that allows for the training of medical examiners who wish to pursue forensics.

Pathologists usually do not see patients, but do on occasion such as when performing bone marrow biopsies र aspirates or fine needle aspirations of superficial nodules. Thus, it is best considered a form of diagnostic medicine. In addition to the diagnosis of disease, including cancer, र the administration of medical laboratories, pathologists often participate in the teaching of medical students Pathology is a core course in the medical curriculum. Pathologists express their opinion as a pathology report addressed to the doctor requesting it. Since pathologists most often communicate with other doctors, they are sometimes nicknamed "the doctors doctor". Pathology is often considered the most scientific branch of medicine because of the available avenues of research involving human material. Finally, the circulation of laboratory data is a central issue in medical informatics र the current tendency towards electronic medical records.


3. Tools of pathology

The techniques used most often in the study of the disease process र hence diagnosis are:

  • Histology: the microscopic study of tissues. Histopathology is the science of diagnosing diseases on the basis of the histological aspect of the diseased tissues.
  • Gross pathology: the recognition of disease based on macroscopic examination of surgical specimens generated at the time of surgery or at autopsy.
  • Immunology: the use of specific immune markers र antibodies to aid in the diagnosis of disease.
  • Cytology: the study of detached cells. Cytopathology is the science of diagnosing diseases on the basis of the cytological aspects of detached cells. The most common application of this technique is the Pap smear.
  • Molecular Biology techniques, like PCR र FISH are increasingly useful to diagnose diseases, especially microbiological र cancer diagnosis.
  • Clinical chemistry: the gathering, detection, र reporting of an incredible array of chemical measures found by the analysis of collected body samples.
  • Flow cytometry:analysis of a process that allows for the identification of specific cells.


4.1. Branches of pathology Medicine

In the United States, pathologists are medical doctors MD or doctors of osteopathic medicine DO, that have completed a four year undergraduate program, four years of medical school training, र four to five years of postgraduate training in the form of a pathology residency. Training may be within two primary specialties, as recognized by the American Board of Pathology:

  • Clinical Pathology, the science of diagnosing diseases based on the analysis of body fluids like blood, urine, etc.
  • Anatomic Pathology, the science of diagnosing diseases based on the appearance, both gross र microscopic appearance of tissues.

Most pathologists seek a broad based training in both fields र thus require four years of postgraduate training known as residency. Finally, a board certification examination is required. Boarding requirements are set by the American Board of Pathology. Pathologists, like all other medical doctors, are also required to meet continuing medical education requirements.


4.2. Branches of pathology Dentistry

The American Board of Oral र maxillofacial pathology certifies dentistry doctors, not medical doctors, to practice this sub-specialty of Pathology.


4.3. Branches of pathology Other

  • Parasitology
  • Plant pathology
  • Veterinary Pathology
  • Speech pathology is an unrelated area mostly involved in helping patients with stroke or speech impediments.
  • Psychopathology is also used in mental health, denoting the study of mental illness.

5. Related sciences

  • Epidemiology: the science of associating diseases with risk factors, regardless of known pathological relationships. An epidemiological association is often the first step in establishing an etiological causal relationship between a risk factor र a disease.
  • Anatomy, either gross or microscopic histology
  • Nosology: the science of classifying, or naming, diseases

6. Other uses of "pathology"

Pathological is used to describe a persons actions in such a way as to credit the action to a disease process, e.g. pathological purchasing or pathological consumption, pathological narcissism, pathological liar, pathological gambling, pathological jealousy. Pathological is also used casually, to signify an abnormal state, e.g. a "pathological attitude" or a "pathological woman hater".

Pathological is also used in mathematics, physics, र statistics to describe an exceptionally or awkwardly, or inconveniently atypical example or set of data, often one which does not abide by rules or succumb to treatment that other similar cases usually do:

  • Pathological science
  • Pathological mathematics

Computer science uses this term in a slightly different sense with regard to the study of algorithms. Here, an input or set of inputs is said to be pathological if it causes atypical behavior from the algorithm, such as a violation of its average case complexity, or even its correctness. For example, hash tables generally have pathological inputs: sets of keys that collide on hash values. The term is often used pejoratively, as a way of dismissing such inputs as being specially designed to break a routine that is otherwise sound in practice.

Forensic Engineers often use the term to describe the underlying causes of distress in structures or machinery in order to specify repairs.

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